Let me point out that gene editing does not sensitize the created being to accepting or being vulnerable to foreign DNA. As for a sort of a joke, the Y chromosome accumulates leftover inactive DNA by it's own to protect itself. (And that is real). So if it is a normal process, (I am firmly against keeping the Y chromosome unaltered in our DNA), All the foreign DNA is metabolised through digestion. If not all gets digested, then you point out to the problem. (Make us and future humans immune to E. Coli by creating a gene or a genetic treatment to do that ;) )
The GMO American Chestnut: Restoration of a Beloved Species or Biotech Trojan Horse?